PRION 2016 TOKYO｜ In Conjunction with：Asian Pacific Prion Symposium 2016

Program

Program

May 7, Sat

13：00～17：30
Young Researcher Training Course (PDF)
Application form (Word)
Application form for APSPR member (Word)
Application form for APSPR member (PDF)

May 8, Sun

9：00～17：30
Young Researcher Training Course

May 9, Mon

9：00～16：30
Young Researcher Training Course

May 10, Tue

9：00～15：30
Animal Prion Diseases Workshop
"Updated Diagnosis and Epidemiology of Animal Prion Diseases for Food Safety and Security"
(Sponsored by the OECD Co-operative Research Programme)
15：30～15：45
Break
 
Opening Lectures
15：45～16：15
Chair: Motomasa Tanaka (RIKEN Brain Science Institute)
OL-1 Reed B. Wickner (NIH)
Implications of the folded in-register parallel beta-sheet structure of infectious prion amyloids
16：15～16：45
Chair: Naomi Hachiya (Tokyo Medical University)
OL-2 Adriano Aguzzi (Institute of Neuropathology, University Hospital of Zürich)
PrPC function and prion toxicity
 
Opening Ceremony
17：00～17：45
President: Hidehiro Mizusawa (PRION2016, NCNP)
Prime Minister: Shinzou Abe (Japanese Government)
President: Fumimaro Takaku (JIDF, JAMS)
President: Makoto Suematsu (AMED)
Co-Chair: Deana Simpson (CJD International Support Alliance, Director, CJD Insight USA)
Co-chair: Suzanne Solvyns (CJD International Support Alliance, Director, CJD Support Group Network, Australia)
Past President: Muneto Ueda (CJD Support Network, Japan)
Association Representative: Debbie Yobs (CJD International Support Alliance, President, CJD Foundation, USA)
Co-Chair: Naoetsu Sodeno (CJD Support Network Japan)
17：45～18：15
PRION 2016 Tokyo Declaration
18：45～
Welcome Reception
Venue: Gakushi kaikan, 2nd floor, Room 201

May 11, Wed

 
Invited Lectures: Conversion and Propagation
Chairs:
Noriyuki Nishida (Nagasaki University)
Glenn Telling (Colorado University)
9：00～9：30
IL-1 Giuseppe Legname (SISSA)
Molecular Determinants of Prions Infectivity
9：30～10：00
IL-2 Claudio Soto (University of Texas)
Potential role of the environment on prion transmission: plants, environmental surfaces and earthworms as carriers of infectious prions
10：00～10：30
IL-3 Jiyan Ma (Van Andel Institute)
How does recombinant prion protein become infectious?
Progress in understanding the molecular basis of prion infectivity
10：30～11：00
IL-4 Keiji Uchiyama (Institute for Enzyme Research, Tokushima University)
Sorting of prion protein and PrPSc accumulation
11：00～11：15
Break
 
Oral Session
11：15～11：30
O-1 Ryo Honda
Folding and misfolding pathways of prion protein
11：30～11：45
O-2 Holger Wille
HET-2s, an engineered, four-rung beta-solenoid protein as a model for the structure of PrPSc.
11：45～12：00
O-3 Mohadeseh Mehrabian
Prion protein deficiency causes diverse proteome shifts in cell models that escape detection in brain tissue
12：10～13：00
Luncheon Seminar 2:
From prion diseases to Alzheimer’s disease
 

Co-sponsored by Daiichi Sankyo Co., Ltd.

Chair:
Hidehiro Mizusawa, M.D., Ph.D. (President / National Center of Neurology and Psychiatry)
Speaker:
Masahito Yamada, M.D., Ph.D. (Professor and Chairman / Department of Neurology & Neurobiology of Aging Kanazawa University Graduate School of Medical Sciences)
 
Invited Lectures: Pathogenesis I
Chairs:
Byron Caughey (NIAID, NIH)
Shigeo Murayama (Tokyo Metropolitan Institute of Gerontology）
13：00～13：30
IL-5 Byron Caughey (NIAID, NIH)
Prion structures, PIRIBS architectures, and real-time quaking-induced conversion (RT-QuIC)
13：30～14：00
IL-6 James W. Ironside (University of Edinburgh)
Neuropathology of prion disease
14：00～14：30
IL-7 Atsushi Kobayashi (Hokkaido University)
Iatrogenic transmission of Creutzfeldt-Jakob disease
14：30～14：45
Break
 
Invited Lectures: Expansion of prion concept
Chairs:
Hidehiro Mizusawa (NCNP)
Joaquin Castilla (CICbioGUNE, Spain)
14：45～15：15
IL-8 Yuji Goto (Osaka University）
Revisiting supersaturation as a factor determining amyloid fibrillation
15：15～15：45
IL-9 Heinrich Roder (Fox Chase Cancer Center)
Mechanisms of prion protein (mis)folding and aggregation explored by ultrafast kinetics
15：45～16：15
IL-10 Masato Hasegawa (Tokyo Metropolitan Institute of Medical Science)
 
Tau / TDP-43 prions
 
Oral Session
16：15～16：30
O-4 Cecile Voisset
Protein Folding Activity of the Ribosome: Key Player in Yeast Prion Propagation
16：30～16：45
O-5 Toshinobu Shida
A local conformation of natively disordered yeast prion monomer determines interspecies prion transmissibility.
16：45～17：00
O-6 Yury Chernoff
Prion nucleation and propagation by amyloid beta in the yeast model
17：00～17：15
Break
17：15～19：15
Poster Session

May 12, Thu

 
Invited Lectures: Pathogenesis II
Chairs:
Shirou Mohri (Tohoku University)
Jean Manson (The Roslin Institute, University of Edinburgh)
9：00～9：30
IL-11 Steven H. Olson (UCSF)
Design of novel anti-prion compounds
9：30～10：00
IL-12 Motohiro Horiuchi (Hokkaido University)
Activation state of glial cells in prion diseases
10：00～10：30
IL-13 Jean-Philippe Deslys (CEA, France)
Transmission of prions to non human-primates: implications for human populations
10：30～10：45
Break
 
Oral Session
10：45～11：00
O-7 Neil Mabbott
Oral prion pathogenesis is reduced in the absence of CXCR5-expressing mononuclear phagocytes
11：00～11：15
O-8 Gabor Kovacs
Tau pathology in Creutzfeldt-Jakob disease: novel insights
11：15～11：30
O-9 Zuzana Krejciova
Creutzfeldt-Jakob disease prion propagation in human iPS cells-derived astrocytes
11：30～11：45
O-10 Chiara zurzolo
Role of Tunneling Nanotubes (TNTs) in intercellular
spreading of prions and other protein
11：45～12：00
O-11 Witold Surewic
Structural role of the middle region in the prion protein in conformational conversion to the infectious form.
12：10～13：00
Luncheon Seminar 3:
Clinicopathological Feature of Genetic Prion Diseases in Japan
 

Co-sponsored by Novartis Pharma K.K.

Chair:
Yoshio Tsuboi (Professor of Department of Neurology, Fukuoka University)
Speaker:
Nobuo Sanjo (Associate Professor of Department of Neurology and Neurological Science, Tokyo Medical and Dental University)
 
Invited Lectures: Human Prion Diseases: Diagnosis
Chairs:
Michael D. Geschwind (UCSF)
Ichiro Takumi (Nippon Medical School)
13：00～13：30
IL-14 Robert Will (National CJD Research and Surveillance Unit, UK)
Variant CJD
13：30～14：00
IL-15 Inga Zerr (Georg August University, Germany)
Genetic prion diseases
14：00～14：30
IL-16 Piero Parchi (University of Bologna)
Biomarkers for prion disease
14：30～14：45
Break
 
Oral Session
14：45～15：00
O-12 Wenquan Zou
PrPSc in the skin of CJD patients
15：00～15：15
O-13 Jiri Safar
Autopsy validation of second generation RT QuIC for diagnosis and differentiation of human prion diseases: results from the US National Prion Disease Pathology Surveillance Center
15：15～15：30
O-14 Luis Concha-Marambio
Highly sensitive and specific detection of prions in blood of vCJD patients by PMCA
 
Invited Lectures: Animal Prion Diseases
Chairs:
Motohiro Horiuchi (Hokkaido University)
Candace Mathiason (Colorado State University)
15：30～16：00
IL-17 Takashi Yokoyama (National Institute of Animal Health, NARO)
Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE: an artificial laboratory strain or possible risk?
16：00～16：30
IL-18 Edward Hoover (Colorado State University)
Rapid analysis of prion seeding activity in clinically accessible biological samples using magnetic particle extraction and realtime conversion
 
Oral Session
16：30～16：45
O-15 Qingzhong Kong
Zoonotic Potential of CWD Prions: An Update
16：45～17：00
O-16 Natalia Fernandez-Borges
Puzzling out the BSE-human transmission barrier
17：00～17：15
Break
17：15～19：15
Poster Session

May 13, Fri

 
Invited Lectures-APPS 2016: Human Prion Diseases: Surveillance
Chairs:
Steve John Collins (University of Melbourne, Australia)
Yoshikazu Nakamura (Jichi Medical University）
9：00～9：30
IL-19 Masahito Yamada (Kanazawa University)
Epidemiological and clinical features of human prion diseases in Japan: prospective 17-year surveillance
9：30～10：00
IL-20 Xiao-Ping Dong (Chinese CDC, China)
Chinese surveillance program for prion diseases
10：00～10：30
IL-21 Shun-Sheng Chen (Kaohsiung Chang Gung Memorial Hospital)
Surveillance of prion diseases in Taiwan
10：30～11：00
IL-22 Yong-Sun Kim (Hallym University)
Real-time quaking-induced conversion analysis for the diagnosis of sporadic Creutzfeldt-Jakob disease in Korea
11：00～11：15
Break
 
-APPS cutting-edge young researcher-
11：15～11：30
O-17 Rodrigo Morales
Acceleration of Abeta brain amyloidosis by peripheral administration of disease associated aggregates.
11：30～11：45
O-18 Ignazio Cali
Amyloid beta pathology in iatrogenic Creutzfeldt-Jakob disease: a multi-center study
11：45～11：55
O-19 Simote Foliaki
Prion acute synaptotoxicity at the CA1 region of the stratum radiatum
11：55～12：05
O-20 Takeshi Yamasaki
Neuron and glial cell type-specific detection of PrPSc in prion-infected mouse brain by flow cytometry
12：10～13：00
Luncheon Seminar 4: α-Synuclein prions
 

Co-sponsored by GlaxoSmithKline K.K.

Chair:
Miho Murata, M.D., PhD. (Director General of National Center Hospital, National Center of Neurology and Psychiatry)
Speaker:
Masato Hasegawa, Ph.D. (Department Head, Department of Dementia and Higher Brain Function Tokyo Metropolitan Institute of Medical Science)
 
Invited Lectures -APPS 2016: Human Prion Diseases: Surveillance / APPS young researcher
Chairs:
Neil Cashman (Vancouver Coastal Health ALS Center)
Yoshio Tsuboi (Fukuoka University)
13：00～13：30
IL-23 John Collinge (National Hospital for Neurology & Neurosurgery, UK)
Therapeutic approaches to prion infection and disease
13：30～14：00
IL-24 Katsumi Doh-ura (Tohoku University)
Lessons from recent outcomes of clinical trials and therapeutic studies
14：00～14：30
IL-25 Fabrizio Tagliavini (Carlo Bestat Neurological Institute)
Prevention trial in fatal familial insomnia
14：30～15：00
IL-26 Kazuo Kuwata (Gifu University)
Logical design of a therapeutic agent for prion diseases
15：00～15：15
Break
 
Oral Session
15：15～15：30
O-21 Ruth Gabizon
Towards prophylactic treatments for carriers of pathogenic PrP mutations
15：30～15：45
O-22 Muhammad Waqas
Eradication of PrPSc by poly-L-arginine in cells infected with prions
15：45～16：00
O-23 Vardiella Meiner
Pre-implantation exclusion of embryos at risk for prion diseases
16：00～17：00
Closing Ceremony
Closing Remarks, Poster Prizes and introduction of PRION2017
18：30～
Gala Dinner
Venue: Azur Takeshiba 14th floor, TENPYO

May 10, Animal Prion Diseases Workshop

9：00～9：05
Opening Remarks
9：05～9：15
OECD programme
Presentation of the OECD CRP programme
Rafael Blasco
CRP Scientific Advisory Board
INIA-Spain

Chair: Motohiro Horiuchi and Corine Lasmezas

9：15～9：45
WS-01 Prion diseases in animals and zoonotic potential
Juan Maria Torres
Laboratory of Molecular and cell biology of prions. Research Center for Animal Health (CISA-INIA).
9：45～10：05
WS-02 Scrapie in Swine: a diagnostic challenge.
Justin Greenlee
Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture
10：05～10：25
WS-03 Epidemiology of Chronic Wasting Disease in Korea
Hyuu-Joo Sohn
Prion Disease Research Laboratory, Animal and Plant Quarantine Agency (QIA), Ministry for Food, Agriculture, Forestry, and Fisheries, Republic of Korea
10：25～10：50
WS-04 Ultra-sensitive detection of PrPSc of classical and atypical BSEs
Yuichi Murayama
National Institue of Animal Health, NARO, Japan

Chair: Yoshfumi Iwamaru and Jean Manson

10：50～11：15
WS-05 RT-QuIC assays in humans and animals
Steven J Collins
Department of Medicine, The University of Melbourne.
11：15～11：45
WS-06 Pathology of TSEs
John Spiropoulos
Animal and Plant Health Agency (APHA)
11：45～12：15
WS-07 Diagnosis of atypical BSE and isolation of the agent
Sandor Dudas
Canadian Food Inspection Agency, National and OIE BSE Reference Laboratory, Lethbridge, Alberta, Canada
12：15～12：45
WS-08 Intra- and interspecies transmission of atypical BSE - what can we learn from it?
Anne Balkema-Buschmann
Friedrich-Loeffler-Institut
Federal Research Institute for Animal Health
Institute of Novel and Emerging Infectious Diseases, Germany
12：45～13：30
Luncheon Seminar 1:
Prion treatment by MC Water and other chemicals

Co-sponsored by Santa Mineral Co., Ltd.

Chair:
Koriki Jojima (Former Minister of Finance)
Speakers:
Takashi Onodera (Professor of University of Tokyo)
Kouichi Furusaki (General incorporated association Mineral Activation Technical Research Center)

Chair: Hiroyuki Okada and John Spiropoulos

13：30～14：00
WS-09 Pathogenesis and transmission of classical and atypical BSEs in cattle
Cristina Casalone
Istituto Zooprofilattico Sperimentale of Turin, Italy
14：00～14：30
WS-10 Neuronal death and prion diseases
Corinne Lasmezas
Department of Infectious Diseases, The Scripps Research Institute, USA
14：30～15：00
WS-11 Evaluating the species barriers of TSEs with transgenic mouse models
Jean Manson
The Roslin Institute, University of Edinburgh, UK

Chair: Toshiro Kawashima and Takashi Yokoyama

15：00～15：30
Closing discussion